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Sildenafil Citrate, most commonly known under the name of Viagra or Revatio is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. It was originally developed by British scientists and it acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Sildenafil Citrate works by ensuring proper blood circulation in the penis region. It removes the blockages in the arteries of the penis thereby leading to free flow of blood to the sexual organ. Sildenafil is the main active ingredient which inhibits the PDE-5 enzyme responsible for managing blood flow in certain areas of the body.
The recommended dose of Sildenafil Citrate products is most patients is 50 mg taken as needed about one hour before sexual activity. It may be taken between 30 minutes and four hours prior to sexual activity. Depending on effect and tolerability, the dose may be increased to a maximum dose of 100 mg daily or reduced to 25 mg daily. It should not be used more than once daily. The active ingredient contained of the substance has the basic function of promoting better circulation throughout the body, but the course of treatment and administration of Sildenafil varies from person to person.
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Sildenafil Citrate is mild in side effects; however users may experience diarrhea, dizziness, flushing, headache, heartburn, upset stomach, fainting, fast or irregular heartbeat, memory loss and a series of allergic reactions. Care should be exercised by patients that are also taking protease inhibitors for the treatment of HIV. Protease inhibitors decrease the metabolism of Sildenafil, multiplying the plasma levels of Sildenafil, increasing the incidence and severity of side effects.
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